In a large skillet over medium-high heat, add the sesame oil. After the oil is hot, add the stew beef and sear until browned on all sides. (You're not cooking the beef through—just giving it a nice golden crust.)
Place the browned beef into your slow cooker.
In a mixing bowl, combine the minced garlic, melted butter, honey, ketchup, soy sauce, and oregano. Whisk until fully blended.
The sauce mixture should be poured over the beef in the crockpot. Stir to coat the beef evenly.
Cover and cook on low for 4–6 hours, or until the beef is fork-tender. The sauce will darken as it cooks due to the soy sauce.
Too Thick? Add ½ cup of water to loosen it. Too Thin? Mix 1 tablespoon of cornstarch with ¼ cup of water, then stir it into the sauce and let it cook for a few more minutes to thicken.
Serve the steak bites over rice or noodles. Garnish with sesame seeds for crunch and fresh parsley or scallions for a pop of color.